Tecan IBL International offers a comprehensive range of ELISAs, antibodies, immunoassays and recombinant proteins for research use only.
Chemokine (C-C Motif) Ligand 8 (CCL8) ELISA Kit
Purpose: The CCL8 ELISA Kit is designed to measure levels of Chemokine (C-C Motif) Ligand 8 (CCL8), also known as Monocyte Chemoattractant Protein-2 (MCP-2), in various biological samples. This assay provides insights into the role of CCL8/MCP-2 in immune responses and disease monitoring.
Background: CCL8/MCP-2 is a 97-amino acid protein that belongs to the C-C subfamily of chemokines. It is secreted by monocytes, fibroblasts, and epithelial cells and is known for its chemotactic activity, attracting CD4+ T cells, CD8+ T cells, monocytes, and natural killer (NK) cells.
While the detailed biological activity of CCL8/MCP-2 in mice is still under investigation, significant findings have emerged in human studies:
- Graft-Versus-Host Disease (GVHD): Elevated levels of CCL8/MCP-2 in plasma have been associated with GVHD, a complication that can arise following bone marrow transplantation. This suggests that CCL8/MCP-2 plays a role in the immune response and could serve as a useful marker for monitoring GVHD and other immune-related conditions.
Significance: The CCL8 ELISA Kit is important for understanding the involvement of CCL8/MCP-2 in immune responses and disease progression. Accurate measurement of CCL8/MCP-2 can aid in:
- Monitoring GVHD: As a potential biomarker for GVHD, CCL8/MCP-2 levels can be used to track the development and progression of this condition.
- Studying Immune Responses: Measuring CCL8/MCP-2 can provide insights into its role in various immune-related diseases and conditions.
Assay Details:
- Detection Method: Enzyme-Linked Immunosorbent Assay (ELISA)
- Target: Chemokine (C-C Motif) Ligand 8 (CCL8) / Monocyte Chemoattractant Protein-2 (MCP-2)
- Specificity: Designed to accurately measure CCL8/MCP-2 levels in biological samples
- Sensitivity: Optimized for detecting low concentrations of CCL8/MCP-2
- Format: Includes ready-to-use reagents and a detailed protocol
- Sample Types: Suitable for plasma, serum, and other relevant biological samples
Utility: The CCL8 ELISA Kit is valuable for:
- Research on Immune Disorders: Understanding the role of CCL8/MCP-2 in immune responses and diseases
- Monitoring Disease Progression: Tracking CCL8/MCP-2 levels in GVHD and other conditions
- Assessing Treatment Efficacy: Evaluating the impact of therapeutic interventions on CCL8/MCP-2 levels
By providing accurate and reliable measurement of CCL8/MCP-2, this ELISA kit supports research and clinical efforts to better understand and manage immune-related conditions.
This ELISA Kit from Tecan IBL International is for research use only.
Tecan IBL International offers a comprehensive range of ELISAs, immunoassays, antibodies and recombinant proteins.
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