mosquito Xtal3 for protein crystallography. 100 nL-5 µL range. Optimized for crystal screening and optimization workflows.
Specialized automation for protein crystallography
The SPT Labtech mosquito Xtal3 is specifically designed for protein crystallography workflows, offering unique nanoliter liquid handling technology for crystal screening and optimization. The system enables researchers to set up thousands of crystallization experiments using minimal protein sample.
Technical Specifications - mosquito Xtal3
• Volume range: 100 nL to 5 µL
• Accuracy: ±5% or 5 nL (whichever is greater)
• Precision: CV ≤3% at 1 µL
• Pipetting technology: Positive displacement with disposable micropipettes
• Configuration: 3-channel with crystallography-optimized deck
• Drop formats: Sitting drop and hanging drop
• Supported plate types: MRC, Swissci, Corning, and custom formats
• Protein volume: As low as 100 nL per drop
• Throughput: Up to 500 drops per hour
Comprehensive crystallography capabilities
Set up sitting drop and hanging drop experiments with precise protein-to-precipitant ratios. Create screening plates using commercial or custom screen solutions. Perform optimization experiments with fine-gradient screens. Miniaturize crystallization experiments to conserve precious protein samples—ideal for membrane proteins and difficult-to-express targets.
Positive displacement for challenging solutions
Handle high-salt precipitants, PEG solutions, and viscous reagents with confidence. True positive displacement technology ensures accurate dispensing regardless of liquid properties. Disposable micropipettes eliminate cross-contamination between different screen conditions.
Integrated with crystallography workflows
Compatible with automated imaging systems for crystal monitoring. Barcode tracking for plate identification. Export data to crystallography databases. Protocol library includes common screens (JCSG+, PACT, Index) and custom screen support.
Maximize hit rates with optimized protocols
Pre-programmed protocols for sparse matrix screening, grid screening, and additive screening. Randomization and replication features for statistical validation. Temperature-controlled deck option for thermally sensitive proteins.