Capillary Electrophoresis Instrument, Automated cIEF & CE-SDS, cIEF fractionation, MauriceFlex

Automated cIEF, CE-SDS Analysis, and cIEF Fractionation in One Platform

MauriceFlex combines protein charge isoform fractionation with imaged-capillary isoelectric focusing (icIEF) and CE-SDS analysis in one instrument, so that you can go beyond routine size and charge analysis and conduct an in-depth characterization of your molecule at any stage without needing to rely on different instruments, methods, or expertise. Get compliant data with either Compass for iCE or Waters Empower software (fractionation not supported on Empower).

Purity, Identity, Heterogeneity, and Charge Variant Fractionation

The potency, safety, and efficacy of your biotherapeutic can be impacted by certain charge variants present, therefore in-depth characterization is crucial. Now, instead of spending weeks or months on ion-exchange chromatography (IEX) based fractionation, detect charge variants of your protein, AND collect their fractions on the same instrument in the same day!

Key Features and Benefits:

• Three capabilities in one platform: cIEF, CE-SDS, and icIEF fractionation
• Charge variant detection and fraction collection in one day
• Replaces time-consuming ion-exchange chromatography methods
• In-depth protein characterization at any development stage
• High-purity fractionation of charge variants
• Sufficient fractions for intact mass analysis and peptide mapping
• Fast results: 10 minutes for cIEF analysis
• High-resolution charge variant separation
• Compatible with downstream LC-MS analysis
• Compliant data with Compass for iCE or Waters Empower
• Platform method development in a day

Applications:

MauriceFlex is ideal for charge variant characterization, protein isoform analysis, post-translational modification studies, biotherapeutic potency assessment, comparability studies, and detailed characterization of mAbs, ADCs, fusion proteins, and other complex biologics.