Tecan IBL International offers a comprehensive range of ELISAs, antibodies, immunoassays and recombinant proteins for research use only.
Tumor Necrosis Factor alpha (TNF-α) is a key cytokine in the immune system with a molecular weight of approximately 17.5 kDa and composed of 157 amino acids. Here’s a detailed overview:
- Function: TNF-α is a potent lymphoid factor known for its ability to exert cytotoxic effects on a wide range of tumor cells and other target cells. It plays a crucial role in inflammation and immune regulation.
- Pro-inflammatory Role: TNF-α is considered a major pro-inflammatory cytokine. It is involved in the pathogenesis of various inflammatory diseases. For instance, it has been detected in the synovial fluid of patients with rheumatoid arthritis, indicating its role in the inflammatory processes of this condition.
- Biosynthesis and Regulation: TNF-α is produced in very small quantities in quiescent (inactive) cells but is significantly upregulated in activated cells. This production is tightly regulated, ensuring that TNF-α levels increase in response to inflammatory stimuli or infection.
- Immune Regulation: TNF-α is a primary mediator of immune responses, influencing various aspects of inflammation, apoptosis (programmed cell death), and cell proliferation.
Due to its central role in inflammation and immune regulation, TNF-α is a target for therapeutic interventions in diseases characterized by excessive inflammation, such as rheumatoid arthritis, Crohn's disease, and certain cancers.
This ELISA Kit from Tecan IBL International is for research use only.
Tecan IBL International offers a comprehensive range of ELISAs, immunoassays, antibodies and recombinant proteins.
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